{"symbol":"RFWD2","synonyms":["COP1","RNF200"],"name":"ring finger and WD repeat domain 2, E3 ubiquitin protein ligase","description":"Enables ubiquitin protein ligase activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to ionizing radiation. Part of Cul4A-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":64326,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/64326","proteins":[{"symbol":"RFWD2_HUMAN","href":"/api/1.0/protein/RFWD2_HUMAN"}],"hgncRootFamilies":[{"name":"WD repeat domain containing (WDR)","href":"/api/1.0/gene_family/WD+repeat+domain+containing+%28WDR%29"},{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}