{"symbol":"RFWD3","synonyms":["RNF201","FANCW"],"name":"ring finger and WD repeat domain 3","description":"Enables MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and response to ionizing radiation. Located in nucleoplasm and site of double-strand break. Implicated in Fanconi anemia complementation group W. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":55159,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/55159","proteins":[{"symbol":"RFWD3_HUMAN","href":"/api/1.0/protein/RFWD3_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"},{"name":"WD repeat domain containing (WDR)","href":"/api/1.0/gene_family/WD+repeat+domain+containing+%28WDR%29"}]}