{"symbol":"RGS10","synonyms":[],"name":"regulator of G-protein signaling 10","description":"Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":6001,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6001","proteins":[{"symbol":"RGS10_HUMAN","href":"/api/1.0/protein/RGS10_HUMAN"}],"hgncRootFamilies":[{"name":"Regulators of G-protein signaling (RGS)","href":"/api/1.0/gene_family/Regulators+of+G-protein+signaling+%28RGS%29"}]}