{"symbol":"RGS18","synonyms":["RGS13"],"name":"regulator of G-protein signaling 18","description":"This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":64407,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/64407","proteins":[{"symbol":"RGS18_HUMAN","href":"/api/1.0/protein/RGS18_HUMAN"}],"hgncRootFamilies":[{"name":"Regulators of G-protein signaling (RGS)","href":"/api/1.0/gene_family/Regulators+of+G-protein+signaling+%28RGS%29"}]}