{"symbol":"RHEB","synonyms":["RHEB2"],"name":"Ras homolog enriched in brain","description":"This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":6009,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6009","proteins":[{"symbol":"RHEB_HUMAN","href":"/api/1.0/protein/RHEB_HUMAN"}],"hgncRootFamilies":[{"name":"Ras small GTPases superfamily","href":"/api/1.0/gene_family/Ras+small+GTPases+superfamily"}]}