{"symbol":"RHOH","synonyms":["TTF","ARHH"],"name":"ras homolog family member H","description":"The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin\u0027s lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5\u0027 untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013]","ncbiEntrezGeneId":399,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/399","proteins":[{"symbol":"RHOH_HUMAN","href":"/api/1.0/protein/RHOH_HUMAN"}],"hgncRootFamilies":[{"name":"Ras small GTPases superfamily","href":"/api/1.0/gene_family/Ras+small+GTPases+superfamily"}]}