{"symbol":"RNASE1","synonyms":["RNS1","RIB1","RAC1"],"name":"ribonuclease, RNase A family, 1 (pancreatic)","description":"This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3\u0027-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2\u0027,3\u0027-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":6035,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6035","proteins":[{"symbol":"RNAS1_HUMAN","href":"/api/1.0/protein/RNAS1_HUMAN"}],"hgncRootFamilies":[{"name":"Ribonucleases, RNase A (RNASE)","href":"/api/1.0/gene_family/Ribonucleases%2C+RNase+A+%28RNASE%29"}]}