{"symbol":"RNASEL","synonyms":["PRCA1"],"name":"ribonuclease L (2\u0027,5\u0027-oligoisoadenylate synthetase-dependent)","description":"This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. The protein is involved in innate immunity and is active against multiple RNA viruses, including the influenza and SARS-CoV-2 viruses. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Nov 2021]","ncbiEntrezGeneId":6041,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6041","proteins":[{"symbol":"RN5A_HUMAN","href":"/api/1.0/protein/RN5A_HUMAN"}],"hgncRootFamilies":[{"name":"Ankyrin repeat domain containing (ANKRD)","href":"/api/1.0/gene_family/Ankyrin+repeat+domain+containing+%28ANKRD%29"}]}