{"symbol":"RNF111","synonyms":["hRNF111","ARK"],"name":"ring finger protein 111","description":"The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]","ncbiEntrezGeneId":54778,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/54778","proteins":[{"symbol":"RN111_HUMAN","href":"/api/1.0/protein/RN111_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}