{"symbol":"RNF139","synonyms":["TRC8"],"name":"ring finger protein 139","description":"The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with  COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":11236,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/11236","proteins":[{"symbol":"RN139_HUMAN","href":"/api/1.0/protein/RN139_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}