{"symbol":"RNF14","synonyms":["TRIAD2","ARA54","HFB30","HRIHFB2038"],"name":"ring finger protein 14","description":"The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]","ncbiEntrezGeneId":9604,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9604","proteins":[{"symbol":"RNF14_HUMAN","href":"/api/1.0/protein/RNF14_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}