{"symbol":"RNF170","synonyms":["SNAX1","ADSA"],"name":"ring finger protein 170","description":"This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]","ncbiEntrezGeneId":81790,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/81790","proteins":[{"symbol":"RN170_HUMAN","href":"/api/1.0/protein/RN170_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}