{"symbol":"RNF186","synonyms":[],"name":"ring finger protein 186","description":"Enables ubiquitin protein ligase activity and ubiquitin protein ligase binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Acts upstream of with a positive effect on regulation of autophagosome assembly. Located in endoplasmic reticulum membrane. Is active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":54546,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/54546","proteins":[{"symbol":"RN186_HUMAN","href":"/api/1.0/protein/RN186_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}