{"symbol":"RNF216","synonyms":["CAHH","TRIAD3","U7I1","UBCE7IP1"],"name":"ring finger protein 216","description":"This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":54476,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/54476","proteins":[{"symbol":"RN216_HUMAN","href":"/api/1.0/protein/RN216_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}