{"symbol":"RNF217","synonyms":["IBRDC1","C6ORF172","OSTL","DJ84N20.1"],"name":"ring finger protein 217","description":"This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]","ncbiEntrezGeneId":154214,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/154214","proteins":[{"symbol":"RN217_HUMAN","href":"/api/1.0/protein/RN217_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}