{"symbol":"RNF34","synonyms":["CARP-1","HRFI","RIFF","CARP1","RFI"],"name":"ring finger protein 34, E3 ubiquitin protein ligase","description":"The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]","ncbiEntrezGeneId":80196,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/80196","proteins":[{"symbol":"RNF34_HUMAN","href":"/api/1.0/protein/RNF34_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}