{"symbol":"RNF8","synonyms":["HRNF8"],"name":"ring finger protein 8, E3 ubiquitin protein ligase","description":"The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]","ncbiEntrezGeneId":9025,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9025","proteins":[{"symbol":"RNF8_HUMAN","href":"/api/1.0/protein/RNF8_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}