{"symbol":"RNH1","synonyms":["RNH"],"name":"ribonuclease/angiogenin inhibitor 1","description":"Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]","ncbiEntrezGeneId":6050,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6050","proteins":[{"symbol":"RINI_HUMAN","href":"/api/1.0/protein/RINI_HUMAN"}],"hgncRootFamilies":[]}