{"symbol":"RNPS1","synonyms":["E5.1"],"name":"RNA binding protein S1, serine-rich domain","description":"This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]","ncbiEntrezGeneId":10921,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10921","proteins":[{"symbol":"RNPS1_HUMAN","href":"/api/1.0/protein/RNPS1_HUMAN"}],"hgncRootFamilies":[{"name":"RNA binding motif containing (RBM)","href":"/api/1.0/gene_family/RNA+binding+motif+containing+%28RBM%29"}]}