{"symbol":"ROBO1","synonyms":["DUTT1"],"name":"roundabout, axon guidance receptor, homolog 1 (Drosophila)","description":"Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]","ncbiEntrezGeneId":6091,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6091","proteins":[{"symbol":"ROBO1_HUMAN","href":"/api/1.0/protein/ROBO1_HUMAN"}],"hgncRootFamilies":[{"name":"Fibronectin type III domain containing","href":"/api/1.0/gene_family/Fibronectin+type+III+domain+containing"},{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}