{"symbol":"ROR1","synonyms":["NTRKR1","DJ537F10.1"],"name":"receptor tyrosine kinase-like orphan receptor 1","description":"This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]","ncbiEntrezGeneId":4919,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4919","proteins":[{"symbol":"ROR1_HUMAN","href":"/api/1.0/protein/ROR1_HUMAN"}],"hgncRootFamilies":[{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"},{"name":"Receptor kinases","href":"/api/1.0/gene_family/Receptor+kinases"}]}