{"symbol":"RPA2","synonyms":["RP-A P34","RP-A P32","REPA2","RPA32"],"name":"replication protein A2, 32kDa","description":"This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017]","ncbiEntrezGeneId":6118,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6118","proteins":[{"symbol":"RFA2_HUMAN","href":"/api/1.0/protein/RFA2_HUMAN"}],"hgncRootFamilies":[]}