{"symbol":"RPS6KA3","synonyms":["MRX19","PP90RSK2","S6K-ALPHA3","CLS","HU-3","P90-RSK2","MAPKAPK1B","ISPK-1","RSK2"],"name":"ribosomal protein S6 kinase, 90kDa, polypeptide 3","description":"This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":6197,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6197","proteins":[{"symbol":"KS6A3_HUMAN","href":"/api/1.0/protein/KS6A3_HUMAN"}],"hgncRootFamilies":[{"name":"X-linked mental retardation","href":"/api/1.0/gene_family/X-linked+mental+retardation"}]}