{"symbol":"RSPO1","synonyms":["CRISTIN3","RSPO"],"name":"R-spondin 1","description":"This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]","ncbiEntrezGeneId":284654,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/284654","proteins":[{"symbol":"RSPO1_HUMAN","href":"/api/1.0/protein/RSPO1_HUMAN"}],"hgncRootFamilies":[{"name":"Endogenous ligands","href":"/api/1.0/gene_family/Endogenous+ligands"}]}