{"symbol":"RSPO2","synonyms":["HHRRD","CRISTIN2","TETAMS2"],"name":"R-spondin 2","description":"This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]","ncbiEntrezGeneId":340419,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/340419","proteins":[{"symbol":"RSPO2_HUMAN","href":"/api/1.0/protein/RSPO2_HUMAN"}],"hgncRootFamilies":[{"name":"Endogenous ligands","href":"/api/1.0/gene_family/Endogenous+ligands"}]}