{"symbol":"RUFY3","synonyms":["SINGAR1","ZFYVE30","RIPX"],"name":"RUN and FYVE domain containing 3","description":"This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]","ncbiEntrezGeneId":22902,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/22902","proteins":[{"symbol":"RUFY3_HUMAN","href":"/api/1.0/protein/RUFY3_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}