{"symbol":"RUNX3","synonyms":["AML2","PEBP2AC","CBFA3"],"name":"runt-related transcription factor 3","description":"This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5\u0027-PYGPYGGT-3\u0027 found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]","ncbiEntrezGeneId":864,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/864","proteins":[{"symbol":"RUNX3_HUMAN","href":"/api/1.0/protein/RUNX3_HUMAN"}],"hgncRootFamilies":[]}