{"symbol":"S100A5","synonyms":["S100D"],"name":"S100 calcium binding protein A5","description":"The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":6276,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6276","proteins":[{"symbol":"S10A5_HUMAN","href":"/api/1.0/protein/S10A5_HUMAN"}],"hgncRootFamilies":[{"name":"S100 calcium binding proteins (S100)","href":"/api/1.0/gene_family/S100+calcium+binding+proteins+%28S100%29"},{"name":"EF-hand domain containing","href":"/api/1.0/gene_family/EF-hand+domain+containing"}]}