{"symbol":"S100A8","synonyms":["60B8AG","NIF","P8","L1Ag","CFAG","CP-10","MRP8","CAGA","CGLA","MA387"],"name":"S100 calcium binding protein A8","description":"The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]","ncbiEntrezGeneId":6279,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6279","proteins":[{"symbol":"S10A8_HUMAN","href":"/api/1.0/protein/S10A8_HUMAN"}],"hgncRootFamilies":[{"name":"EF-hand domain containing","href":"/api/1.0/gene_family/EF-hand+domain+containing"},{"name":"S100 calcium binding proteins (S100)","href":"/api/1.0/gene_family/S100+calcium+binding+proteins+%28S100%29"}]}