{"symbol":"S1PR5","synonyms":["S1P5","SPPR-1","EDG-8","SPPR-2","EDG8"],"name":"sphingosine-1-phosphate receptor 5","description":"The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]","ncbiEntrezGeneId":53637,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/53637","proteins":[{"symbol":"S1PR5_HUMAN","href":"/api/1.0/protein/S1PR5_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}