{"symbol":"SAE1","synonyms":["UBLE1A","AOS1","SUA1","HSPC140"],"name":"SUMO1 activating enzyme subunit 1","description":"Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]","ncbiEntrezGeneId":10055,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10055","proteins":[{"symbol":"SAE1_HUMAN","href":"/api/1.0/protein/SAE1_HUMAN"}],"hgncRootFamilies":[{"name":"Ubiquitin-like activating enzymes (UBA)","href":"/api/1.0/gene_family/Ubiquitin-like+activating+enzymes+%28UBA%29"}]}