{"symbol":"SAP18","synonyms":["2HOR0202","SAP18P"],"name":"Sin3A-associated protein, 18kDa","description":"Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]","ncbiEntrezGeneId":10284,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10284","proteins":[{"symbol":"SAP18_HUMAN","href":"/api/1.0/protein/SAP18_HUMAN"}],"hgncRootFamilies":[]}