{"symbol":"SDC1","synonyms":["SYNDECAN","SDC","SYND1","CD138"],"name":"syndecan 1","description":"The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":6382,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6382","proteins":[{"symbol":"SDC1_HUMAN","href":"/api/1.0/protein/SDC1_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"Proteoglycans","href":"/api/1.0/gene_family/Proteoglycans"}]}