{"symbol":"SDHA","synonyms":["SDHF","SDH1","PGL5","SDH2","CMD1GG"],"name":"succinate dehydrogenase complex, subunit A, flavoprotein (Fp)","description":"This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]","ncbiEntrezGeneId":6389,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6389","proteins":[{"symbol":"SDHA_HUMAN","href":"/api/1.0/protein/SDHA_HUMAN"}],"hgncRootFamilies":[{"name":"Mitochondrial respiratory chain complexes","href":"/api/1.0/gene_family/Mitochondrial+respiratory+chain+complexes"}]}