{"symbol":"SEMA3E","synonyms":["SEMAH","M-SEMAH","COLL-5","M-SEMAK"],"name":"sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E","description":"Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]","ncbiEntrezGeneId":9723,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9723","proteins":[{"symbol":"SEM3E_HUMAN","href":"/api/1.0/protein/SEM3E_HUMAN"}],"hgncRootFamilies":[{"name":"Semaphorins (SEMA)","href":"/api/1.0/gene_family/Semaphorins+%28SEMA%29"},{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}