{"symbol":"SEMA4G","synonyms":[],"name":"sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G","description":"Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]","ncbiEntrezGeneId":57715,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/57715","proteins":[{"symbol":"SEM4G_HUMAN","href":"/api/1.0/protein/SEM4G_HUMAN"}],"hgncRootFamilies":[{"name":"Semaphorins (SEMA)","href":"/api/1.0/gene_family/Semaphorins+%28SEMA%29"},{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}