{"symbol":"SENP3","synonyms":["ULP1","SSP3","SMT3IP1"],"name":"SUMO1/sentrin/SMT3 specific peptidase 3","description":"The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]","ncbiEntrezGeneId":26168,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/26168","proteins":[{"symbol":"SENP3_HUMAN","href":"/api/1.0/protein/SENP3_HUMAN"}],"hgncRootFamilies":[]}