{"symbol":"SEPT5-GP1BB","synonyms":["GPIb-beta","GP1BB"],"name":"SEPT5-GP1BB readthrough","description":"This locus represents naturally occurring read-through transcription between the neighboring SEPT5 (septin 5) and GP1BB (glycoprotein Ib (platelet), beta polypeptide) genes on chromosome 22. This read-through transcription arises from inefficient use of an imperfect polyA signal in the upstream SEPT5 gene, whereby transcription continues into the GP1BB gene. Alternative splicing results in multiple read-through variants. The read-through transcripts are candidates for nonsense-mediated mRNA decay (NMD), and are therefore unlikely to produce protein products. [provided by RefSeq, Dec 2010]","ncbiEntrezGeneId":100526833,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/100526833","proteins":[],"hgncRootFamilies":[]}