{"symbol":"SERPINF2","synonyms":["A2AP","PLI","API","AAP","ALPHA-2-PI"],"name":"serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2","description":"This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]","ncbiEntrezGeneId":5345,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5345","proteins":[{"symbol":"A2AP_HUMAN","href":"/api/1.0/protein/A2AP_HUMAN"}],"hgncRootFamilies":[{"name":"Serpin peptidase inhibitors (SERPIN)","href":"/api/1.0/gene_family/Serpin+peptidase+inhibitors+%28SERPIN%29"}]}