{"symbol":"SESN1","synonyms":["PA26","SEST1"],"name":"sestrin 1","description":"This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]","ncbiEntrezGeneId":27244,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/27244","proteins":[{"symbol":"SESN1_HUMAN","href":"/api/1.0/protein/SESN1_HUMAN"}],"hgncRootFamilies":[]}