{"symbol":"SETDB1","synonyms":["KG1T","H3-K9-HMTASE4","ESET","TDRD21","KMT1E"],"name":"SET domain, bifurcated 1","description":"This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]","ncbiEntrezGeneId":9869,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9869","proteins":[{"symbol":"SETB1_HUMAN","href":"/api/1.0/protein/SETB1_HUMAN"}],"hgncRootFamilies":[{"name":"Tudor domain containing (TDRD)","href":"/api/1.0/gene_family/Tudor+domain+containing+%28TDRD%29"},{"name":"Chromatin-modifying enzymes","href":"/api/1.0/gene_family/Chromatin-modifying+enzymes"}]}