{"symbol":"SETDB2","synonyms":["C13ORF4","CLLL8","KMT1F","CLLD8"],"name":"SET domain, bifurcated 2","description":"This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]","ncbiEntrezGeneId":83852,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/83852","proteins":[{"symbol":"SETB2_HUMAN","href":"/api/1.0/protein/SETB2_HUMAN"}],"hgncRootFamilies":[{"name":"Chromatin-modifying enzymes","href":"/api/1.0/gene_family/Chromatin-modifying+enzymes"}]}