{"symbol":"SETMAR","synonyms":["METNASE","Mar1","HSMAR1"],"name":"SET domain and mariner transposase fusion gene","description":"This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]","ncbiEntrezGeneId":6419,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6419","proteins":[{"symbol":"SETMR_HUMAN","href":"/api/1.0/protein/SETMR_HUMAN"}],"hgncRootFamilies":[]}