{"symbol":"SF3A2","synonyms":["SAP62","SF3A66","PRP11","PRPF11"],"name":"splicing factor 3a, subunit 2, 66kDa","description":"This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":8175,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8175","proteins":[{"symbol":"SF3A2_HUMAN","href":"/api/1.0/protein/SF3A2_HUMAN"}],"hgncRootFamilies":[]}