{"symbol":"SF3A3","synonyms":["PRP9","SAP61","PRPF9","SF3A60"],"name":"splicing factor 3a, subunit 3, 60kDa","description":"This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]","ncbiEntrezGeneId":10946,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10946","proteins":[{"symbol":"SF3A3_HUMAN","href":"/api/1.0/protein/SF3A3_HUMAN"}],"hgncRootFamilies":[]}