{"symbol":"SF3B1","synonyms":["SF3B155","HSH155","PRPF10","PRP10","SAP155"],"name":"splicing factor 3b, subunit 1, 155kDa","description":"This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron\u0027s branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":23451,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23451","proteins":[{"symbol":"SF3B1_HUMAN","href":"/api/1.0/protein/SF3B1_HUMAN"}],"hgncRootFamilies":[]}