{"symbol":"SF3B2","synonyms":["SF3B150","SF3b1","SF3B145","SAP145","CUS1"],"name":"splicing factor 3b, subunit 2, 145kDa","description":"This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron\u0027s branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":10992,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10992","proteins":[{"symbol":"SF3B2_HUMAN","href":"/api/1.0/protein/SF3B2_HUMAN"}],"hgncRootFamilies":[]}