{"symbol":"SF3B3","synonyms":["RSE1","SF3B130","STAF130","SAP130"],"name":"splicing factor 3b, subunit 3, 130kDa","description":"This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron\u0027s branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":23450,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23450","proteins":[{"symbol":"SF3B3_HUMAN","href":"/api/1.0/protein/SF3B3_HUMAN"}],"hgncRootFamilies":[]}