{"symbol":"SF3B4","synonyms":["HSH49","SF3B49","AFD1","SAP49"],"name":"splicing factor 3b, subunit 4, 49kDa","description":"This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":10262,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10262","proteins":[{"symbol":"SF3B4_HUMAN","href":"/api/1.0/protein/SF3B4_HUMAN"}],"hgncRootFamilies":[{"name":"RNA binding motif containing (RBM)","href":"/api/1.0/gene_family/RNA+binding+motif+containing+%28RBM%29"}]}