{"symbol":"SFPQ","synonyms":["POMP100","PPP1R140"],"name":"splicing factor proline/glutamine-rich","description":"Enables DNA binding activity; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including alternative mRNA splicing, via spliceosome; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and regulation of transcription by RNA polymerase II. Acts upstream of or within double-strand break repair via homologous recombination. Located in chromatin; nuclear matrix; and paraspeckles. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":6421,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6421","proteins":[{"symbol":"SFPQ_HUMAN","href":"/api/1.0/protein/SFPQ_HUMAN"}],"hgncRootFamilies":[{"name":"RNA binding motif containing (RBM)","href":"/api/1.0/gene_family/RNA+binding+motif+containing+%28RBM%29"},{"name":"Protein phosphatase 1 regulatory subunits (PPP1R)","href":"/api/1.0/gene_family/Protein+phosphatase+1+regulatory+subunits+%28PPP1R%29"}]}